what disease have this symptom "ANA+,anti ds DNA+,ss-A+,antiPL+,anti SM+,Anti histon+"?

Answers:
This combination of positive autoantibody tests is stongly suggestive of some form of lupus erythematosus. In particular, the anti-SM test is positive in about a third of subjects ultimately diagnosed as having systemic lupus (SLE), but almost never in other autoimmune diseases. This makes it about as specific for SLE as tests in rheumatology ever are. The anti-nuclear antibody test (anti-ANA) is positive in up to 99% of true cases of SLE, but it can also be positive in other autoimmune diseases, in people taking certain medications, and among health elderly people. This makes it a much less specific indicator of SLE. The anti-histone antibody test is interesting because it can be used to differentiate between drug-induced lupus and SLE (idiopathic lupus). Thus, the array of positive antibody tests listed in the question suggests drug-induced lupus erythematosus. Drugs sometimes associated with this condition include procainamide, isoniazid, chlorpromazine, penicillamine, sulfasalazine, hydralazine, methyldopa, and quinidine. Drug-induced lupus is usually less severe than SLE, and the symptoms will tend to disappear shortly after the person stops taking the medication.

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SLE?

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Sjogren's

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